In memory of a game-changing haematologist



In memory of a game-changing haematologist

Haematology has lost a giant: Paul Sylvain Frenette died in July, aged 56. His research led directly to the development of therapies that changed clinical practice. And he taught us — his former trainees — by example and shaped our careers.

Frenette was the inaugural director of the Ruth L. and David S. Gottesman Institute for Stem Cell Biology and Regenerative Medicine at Albert Einstein College of Medicine in New York City, where he built one of the strongest interdisciplinary stem-cell programmes in the United States. He developed new paradigms across a range of haematology topics.

For example, he helped to discover the mechanisms mediating vaso-occlusion in sickle-cell disease (A. Turhan et al. Proc. Natl Acad. Sci. USA 99, 3047–3051; 2002); to define how the nervous system regulates haematopoiesis (Y. Katayama et al. Cell 124, 407–421; 2006); and to identify fundamental components and mechanisms through which the bone marrow niche regulates haematopoietic stem cells (see, for example, S. Méndez-Ferrer et al. Nature 466, 829–834; 2010).

As a stellar academic, Frenette trained and influenced many scientists. He encouraged us to identify the key significance of our hypotheses and to do the best experiments to prove them.

Nature 597, 31 (2021)


Competing Interests

The authors declare no competing interests.


Nature Careers


Nature Briefing

An essential round-up of science news, opinion and analysis, delivered to your inbox every weekday.

Products You May Like

Articles You May Like

Google’s Pixel 6 camera smartens up snapshots with AI tools
NASA expects vaccination mandates to have little impact on Artemis 1 preparations
The climate policies tucked into Congress’ budget package are signals to investors
Analogue aspires to build the definitive OS for retro gaming
MIT spinoff Via Separations scores $38M Series B to decarbonize manufacturing

Leave a Reply